Transcutol® helps our formulators keep high concentrations to better guide the active ingredients. Transcutol® is added to “alpha-gel” structure created by the emulsifier, and it becomes like a second skin, a rigid but flexible gel that retains more water and creates a protective film on the skin. The greater hydration leads to more channelling in the deeper layers of the dermis. The same molecule is clinically tested for drugs with optimal tolerance: up to half of the applied solvent crosses the skin’s barrier and becomes systemic. In summary, the action of TC as a penetration enhancer could be attributed, on one hand, to its permeation into the skin and its effect on the partition behaviour of a drug, and on the other hand, to the hydration of TC which can absorb water not only from the air, but also from the skin (change of vehicle composition) improving the skin penetration of certain drugs, maximizing its thermodynamic activity due to a change of drug solubility (Ritschel and Hussain, 1988; Bialik et al., 1993).
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